Article

Repopulated microglia induce expression of Cxcl13 with modest changes in Tau phosphorylation but do not impact amyloid pathology

2022-03-14

Abstract excerpt

<h4>Background: </h4> Adult microglia rely on self-renewal through division to repopulate and sustain their numbers. However, with aging, microglia display morphological and transcriptional changes that reflect a heightened state of neuroinflammation. This state threatens aging neurons and other cells and can influence the progression of Alzheimer's disease (AD). In this study, we sought to determine whether renew...

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Literature Corpus work: e201c56e-1176-57cf-9ec1-f732468dce4e
DOI: 10.21203/rs.3.rs-1435003/v1

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