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Article

Splicing the Difference: Harnessing the Complexity of the Transcriptome in Hematopoiesis.

Experimental hematology - 1 Dec 2024

Maul-Newby Hannah M, Halene Stephanie

Abstract excerpt

Alternative splicing has long been recognized as a powerful tool to expand the diversity of the transcriptome and the proteome. The study of hematopoiesis, from hematopoietic stem cell maintenance and differentiation into committed progenitors to maturation into functional blood cells, has led the field of stem cell research and cellular differentiation for decades. The importance of aberrant splicing due to...

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PMID: 39393608
DOI: 10.1016/j.exphem.2024.104655

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