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Article

Postpartum breast cancer has a distinct molecular profile that predicts poor outcomes.

Nature communications - 3 Nov 2021

Jindal Sonali, Pennock Nathan D, Sun Duanchen, Horton Wesley, Ozaki Michelle K, Narasimhan Jayasri, Bartlett Alexandra Q, Weinmann Sheila, Goss Paul E, Borges Virginia F, Xia Zheng, Schedin Pepper

Abstract excerpt

Young women's breast cancer (YWBC) has poor prognosis and known interactions with parity. Women diagnosed within 5-10 years of childbirth, defined as postpartum breast cancer (PPBC), have poorer prognosis compared to age, stage, and biologic subtype-matched nulliparous patients. Genomic differences that explain this poor prognosis remain unknown. In this study, using RNA expression data from clinically matched...

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Identifiers

PMID: 34732713
DOI: 10.1038/s41467-021-26505-3
PMCID: PMC8566602

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