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The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival

1 Oct 2010

Abstract excerpt

eIF4E is over-expressed in many tumours, including a high proportion of breast cancers. eIF4E is an oncogene, and signalling pathways which promote eIF4E activity represent potential targets for therapeutic intervention in cancer. MNKs phosphorylate eIF4E on serine 209, a modification that can be required for eIF4E-dependent cell transformation. There is therefore a clear requirement to determine the role of MNKs...

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PMID: 20686366
DOI: 10.4161/cbt.10.7.12965

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