Article
Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages.
Oncotarget - 13 Dec 2016
Smirnova Tatiana, Bonapace Laura, MacDonald Gwen, Kondo Shunya, Wyckoff Jeffrey, Ebersbach Hilmar, Fayard Bérengère, Doelemeyer Arno, Coissieux Marie-May, Heideman Marinus R, Bentires-Alj Mohamed, Hynes Nancy E
Abstract excerpt
The extracellular serine protease inhibitor serpinE2 is overexpressed in breast cancer and has been shown to foster metastatic spread. Here, we investigated the hypothesis that serpinE2 creates tumor-promoting conditions in the tumor microenvironment (TME) by affecting extracellular matrix remodeling. Using two different breast cancer models, we show that blocking serpinE2, either by knock-down (KD) in tumor...
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