Article
Using genome-wide pathway analysis to unravel the etiology of complex diseases.
Genetic epidemiology - 1 Jul 2009
Elbers Clara C, van Eijk Kristel R, Franke Lude, Mulder Flip, van der Schouw Yvonne T, Wijmenga Cisca, Onland-Moret N Charlotte
Abstract excerpt
Several genome-wide association studies (GWAS) have been published on various complex diseases. Although, new loci are found to be associated with these diseases, still only very little of the genetic risk for these diseases can be explained. As GWAS are still underpowered to find small main effects, and gene-gene interactions are likely to play a role, the data might currently not be analyzed to its full...
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