Article
Lack of Transmission of Chronic Wasting Disease Prions to Human Cerebral Organoids.
Emerging infectious diseases - 1 Jun 2024
Groveman Bradley R, Williams Katie, Race Brent, Foliaki Simote, Thomas Tina, Hughson Andrew G, Walters Ryan O, Zou Wenquan, Haigh Cathryn L
Abstract excerpt
Chronic wasting disease (CWD) is a cervid prion disease with unknown zoonotic potential that might pose a risk to humans who are exposed. To assess the potential of CWD to infect human neural tissue, we used human cerebral organoids with 2 different prion genotypes, 1 of which has previously been associated with susceptibility to zoonotic prion disease. We exposed organoids from both genotypes to high...
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