Article
Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases
13 Feb 2021
Abstract excerpt
The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP-seq in four clonal metastatic tumors derived from a single prostate cancer patient. Our epigenomic analyses focused on androgen receptor (AR), which is a key oncogenic driver in prostate cancer, the AR...
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