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Association of B7‐H3 expression with racial ancestry, immune cell density, and androgen receptor activation in prostate cancer

25 Mar 2022

Abstract excerpt

BACKGROUND: B7 homolog 3 (B7-H3) is an immunomodulatory molecule that is highly expressed in prostate cancer (PCa) and belongs to the B7 superfamily, which includes PD-L1. Immunotherapies (antibodies, antibody-drug conjugates, and chimeric antigen receptor T cells) targeting B7-H3 are currently in clinical trials; therefore, elucidating the molecular and immune microenvironment correlates of B7-H3 expression may...

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PMID: 35333400
DOI: 10.1002/cncr.34190

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