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Article

Metabolic Phenotyping of Healthy and Diseased Human RPE Cells.

Investigative ophthalmology & visual science - 3 Sept 2024

Rizwan Saira, Toothman Beverly, Li Bo, Engel Abbi L, Lim Rayne R, Niernberger Sheldon, Lu Jinyu, Ratliff Cloe, Xiang Yinxiao, Eminhizer Mark, Chao Jennifer R, Du Jianhai

Abstract excerpt

Purpose: Metabolic defects in the retinal pigment epithelium (RPE) underlie many retinal degenerative diseases. This study aims to identify the nutrient requirements of healthy and diseased human RPE cells. Methods: We profiled nutrient use of various human RPE cells, including differentiated and dedifferentiated fetal RPE (fRPE), induced pluripotent stem cell-derived RPE (iPSC RPE), Sorsby fundus dystrophy (SFD)...

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Source

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Identifiers

PMID: 39230994
DOI: 10.1167/iovs.65.11.5
PMCID: PMC11379083

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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