Article

Learning a Continuous Progression Trajectory of Amyloid in Alzheimer disease

2026-02-06

Abstract excerpt

<h4>BACKGROUND</h4> Understanding of early Alzheimer progression is critical for timely diagnosis and treatment evaluation, but traditional diagnostic groups often lack sensitivity to subtle early-stage changes. <h4>METHODS</h4> We developed SLOPE, an unsupervised dimensionality reduction method that models the amyloid progression in AD on a continuous scale which preserves the temporal sequence of follow-up vis...

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Literature Corpus work: 0422a176-e061-554b-8483-671a332c9c62
DOI: 10.64898/2026.02.03.703568

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