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Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks

3 Feb 2022

Abstract excerpt

Identifying the molecular systems and proteins that modify the progression of Alzheimer's disease and related dementias (ADRD) is central to drug target selection. However, discordance between mRNA and protein abundance, and the scarcity of proteomic data, has limited our ability to advance candidate targets that are mainly based on gene expression. Therefore, by using a deep neural network that predicts protein...

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PMID: 35115553
DOI: 10.1038/s41467-022-28280-1

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