Article

Polypharmacologic Disruption of the Proliferative-to-Mesenchymal Fate Branch Point Reverses EndMT and Pulmonary Hypertension

2026-07-23

Abstract excerpt

<title>Abstract</title> <p>Endothelial-to-mesenchymal transition (EndMT) drives vascular remodeling in pulmonary arterial hypertension (PAH), yet the regulators that commit endothelial cells to this fate and whether they are pharmacologically addressable remain poorly defined. We report TK22, a small molecule that selectively erases the EndMT-competent endothelial state and reverses experimental pulmonary hyperte...

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Literature Corpus work: e1a2e383-4219-5efb-a67f-342f3c06ffdd
DOI: 10.21203/rs.3.rs-9306408/v2

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Polypharmacologic Disruption of the Proliferative-to-Mesenchymal Fate Branch Point Reverses EndMT and Pulmonary HypertensionDOI 10.21203/rs.3.rs-9306408/v2Read

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