Article

Pulmonary Arterial Hypertension Induces a Metabolic and Inflammatory Hepatopathy

2026-03-18

Abstract excerpt

Right ventricular failure (RVF) is a robust predictor of mortality in pulmonary arterial hypertension (PAH); however, the mechanisms linking RVF to end-organ dysfunction remain unclear. Hepatic impairments portend poor outcomes in PAH, but the cell-specific effects of PAH on the human liver are unknown. Here, we performed single nucleus RNA sequencing on autopsy-derived liver tissue from five PAH patients and four...

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Literature Corpus work: 476bb474-ac43-58b2-b37b-19560f59863d
DOI: 10.64898/2026.03.16.712114

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