Article

Early postnatal DNA methylation dynamics define neuronal subtypes and are disrupted by MECP2 loss

2026-06-08

Abstract excerpt

DNA methylation is the foundational layer of epigenetic regulation underlying mammalian tissue specification. During synaptogenesis, neurons accumulate high levels of a unique type of methylation in which a cytosine precedes a C, A, or T (mCH) instead of the canonical guanine (mCG). Disruption of the mCH reader methyl-CpG binding protein 2 (MECP2) causes the devastating neurodevelopmental disorder Rett syndrome, y...

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Literature Corpus work: e19f6007-1b2d-5cf1-8ad2-7db6b0ad49a7
DOI: 10.64898/2026.06.06.730504

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