Article

A Regulatory Axis for Tonotopic MYO7A Expression in Cochlear Hair Cells

2025-04-05

Abstract excerpt

Myo7a , a gene mutated in Usher syndrome and non-syndromic deafness, encodes an unconventional myosin essential for hair cell function. Our previous work revealed that cochlear hair cells express distinct Myo7a isoforms with unique spatial and cell type-specific patterns. The canonical isoform ( Myo7a-C ) and a novel isoform ( Myo7a-N ) are co-expressed in outer hair cells (OHCs) but exhibit opposing tonotopic...

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Literature Corpus work: e1979bbe-adcc-5ad4-9658-cf9e34940733
DOI: 10.1101/2025.04.04.647241

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