Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Apr 2015

Cai Tiantian, Jen Hsin-I, Kang Hyojin, Klisch Tiemo J, Zoghbi Huda Y, Groves Andrew K

Abstract excerpt

Hair cells are sensory receptors for the auditory and vestibular system in vertebrates. The transcription factor Atoh1 is both necessary and sufficient for the differentiation of hair cells, and is strongly upregulated during hair-cell regeneration in nonmammalian vertebrates. To identify genes involved in hair cell development and function, we performed RNA-seq profiling of purified Atoh1-expressing hair cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve Tissue Proteins
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Immunoprecipitation

Share to Gene Ontology

Share to Hair Cells, Auditory

Share to Luminescent Proteins

Share to Mice, Transgenic

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 25855195
DOI: 10.1523/JNEUROSCI.5083-14.2015
PMCID: PMC4388939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor.PMID 25855195Read ↗

Generation and characterization of Atoh1-Cre knock-in mouse line.Semantic proximity Read ↗

Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner earsSemantic proximity Read ↗

Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch.Semantic proximity Read ↗

Single-cell atlas comparison across vertebrates reveals evolution of auditory cell types and mechanisms for hair cell regenerationSemantic proximity Read ↗

Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2.Semantic proximity Read ↗

Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.Semantic proximity Read ↗

Single-cell RNA-sequencing of zebrafish hair cells reveals the novel genes potentially involved in hearing lossSemantic proximity Read ↗

Single-Cell Transcriptomic Profiling of the Zebrafish Inner Ear Reveals Molecularly Distinct Hair Cell and Supporting Cell SubtypesSemantic proximity Read ↗

Development of the Mouse and Human Cochlea at Single Cell ResolutionSemantic proximity Read ↗

Simultaneous gentamicin-mediated damage and Atoh1 overexpression promotes hair cell regeneration in the neonatal mouse utricleSemantic proximity Read ↗

Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter.Semantic proximity Read ↗

Open chromatin dynamics in prosensory cells of the embryonic mouse cochlea.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.