Article
Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells.
Development (Cambridge, England) - 1 Feb 1998
Self T, Mahony M, Fleming J, Walsh J, Brown S D, Steel K P
Abstract excerpt
The mouse shaker-1 locus, Myo7a, encodes myosin VIIA and mutations in the orthologous gene in humans cause Usher syndrome type 1B or non-syndromic deafness. Myo7a is expressed very early in sensory hair cell development in the inner ear. We describe the effects of three mutations on cochlear hair...
Topics
- Animals
- Animals, Newborn
- Base Sequence
- Cilia
- DNA Primers
- Dyneins
- Electrophysiology
- Hair Cells, Auditory
- Humans
- In Situ Hybridization
- Mice
- Mice, Mutant Strains
- Microscopy, Electron
- Microscopy, Electron, Scanning
- Mutation
- Myosin VIIa
- Myosins