Article

Novel islands of GGC and GCC repeats coincide with human evolution

2023-07-17

Abstract excerpt

<h4>Background: </h4> Because of high mutation rate, overrepresentation in genic regions, and link with various neurological, neurodegenerative, and movement disorders, GGC and GCC short tandem repeats (STRs) are prone to natural selection. Among a number of lacking data on those STRs, the 3-repeats of these STRs remain widely unexplored. Results In a genome-wide search in human, here we mapped GGC and GCC STRs o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ec940ba7-57c5-5cc1-aa9f-5aab96de7cda
DOI: 10.21203/rs.3.rs-3159062/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel islands of GGC and GCC repeats coincide with human evolutionDOI 10.21203/rs.3.rs-3159062/v1Read

Unprecedented islands of GGC and GCC repeats coincide with human evolution.Semantic proximity Read

Dyads of GGC and GCC form hotspot colonies that coincide with the evolution of human and other great apes.Semantic proximity Read

Profiling human pathogenic repeat expansion regions by synergistic and multi-level impacts on molecular connectionsSemantic proximity Read

Abundancy of polymorphic CGG repeats in the human genome suggest a broad involvement in neurological disease.Semantic proximity Read

A primate-specific (GCC) repeat in the untranslated region of SMAD9 undergoes natural selection and links with late-onset neurocognitive disorder in humanSemantic proximity Read

Analysis of genomic loci harboring 59,732 human-specific regulatory sequences reveals unique to human regulatory patterns associated with brain developmentSemantic proximity Read

Two-repeat units of CG-rich trinucleotides form long-sought hotspot loci shared across primates and mouseSemantic proximity Read

Patterns of low-complexity regions in human genesSemantic proximity Read

Evolutionary trend of exceptionally long human core promoter short tandem repeats.Semantic proximity Read

A primate-specific (GCC) repeat in SMAD9 undergoes natural selection in humans and harbors unambiguous genotypes in late-onset neurocognitive disorder.Semantic proximity Read

Computational and experimental hunt for expansion prone tandem CNG repeats in human genomesSemantic proximity Read

A (GCC) repeat in SBF1 reveals a novel biological phenomenon in human and links to late onset neurocognitive disorder.Semantic proximity Read