Article

Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)

2025-03-16

Abstract excerpt

<h4>SUMMARY</h4> Ubiquitin-specific protease 7 (USP7) is a deubiquitylase essential for cell homeostasis, DNA repair, and regulation of both tumor suppressors and oncogenes. Inactivating USP7 mutations have been associated with Hao-Fountain Syndrome (HAFOUS), a rare neurodevelopmental disorder. Although a range of USP7 inhibitors have been developed over the last decade, in the context of HAFOUS as well as oncoge...

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Literature Corpus work: e15db143-6d83-5833-92dc-42a15d0b7bc6
DOI: 10.1101/2025.03.14.643379

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