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Article

Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation.

Structure (London, England : 1993) - 2 Jan 2018

Özen Ayşegül, Rougé Lionel, Bashore Charlene, Hearn Brian R, Skelton Nicholas J, Dueber Erin C

Abstract excerpt

Ubiquitin-specific protease 7 (USP7) deubiquitinase activity is controlled by a number of regulatory factors, including stimulation by intramolecular accessory domains. Alone, the USP7 catalytic domain (USP7cd) shows limited activity and apo USP7cd crystal structures reveal a disrupted catalytic triad. By contrast, ubiquitin-conjugated USP7cd structures demonstrate the canonical cysteine protease active-site...

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Catalytic Domain
Hydrophobic and Hydrophilic Interactions
Molecular Dynamics Simulation
Protein Conformation, alpha-Helical
Protein Conformation, beta-Strand

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Interaction Domains and Motifs

Static Electricity

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Identifiers

PMID: 29249604
DOI: 10.1016/j.str.2017.11.010

Genes

USP7

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