Article

Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1

2024-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Pathogenic variants in the ubiquitin-specific protease 7 ( USP7 ) gene cause a neurodevelopmental disorder called Hao-Fountain syndrome. However, which of USP7’s pleiotropic functions are relevant for neurodevelopment remains unclear. Here, we present a combination of quantitative proteomics, transcriptomics and epigenomics to define the USP7 regulatory circuitry during neuronal differentiation...

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Literature Corpus work: 38331744-2d9c-5286-bd7d-cb962a8f5ff7
DOI: 10.1101/2024.08.04.606521

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