Article

Activation Dynamics of Ubiquitin Specific Protease 7

2023-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme responsible for the regulation of key human oncoproteins and tumor suppressors including Mdm2 and p53, respectively. Unlike other members of the USP family of proteases, the isolated catalytic domain of USP7 adopts an enzymatically inactive conformation that has been well characterized using X-ray crystallography. The catalytic do...

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Literature Corpus work: b3104a56-7235-5ed5-9478-7c5a00e45c57
DOI: 10.1101/2023.01.11.523550

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