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Article

Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk.

Molecular psychiatry - 1 Sept 2008

Nicodemus K K, Marenco S, Batten A J, Vakkalanka R, Egan M F, Straub R E, Weinberger D R

Abstract excerpt

The etiology of schizophrenia is thought to include both epistasis and gene-environment interactions. We sought to test whether a set of schizophrenia candidate genes regulated by hypoxia or involved in vascular function in the brain (AKT1, BDNF, CAPON, CHRNA7, COMT, DTNBP1, GAD1, GRM3, NOTCH4, NRG1, PRODH, RGS4, TNF-alpha) interacted with serious obstetric complications to influence risk for schizophrenia. A...

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Source

Identifiers

PMID: 18195713
DOI: 10.1038/sj.mp.4002153

Genes

AKT1
BDNF
DTNBP1
GRM3
CHRNA7
COMT
GAD1
NOTCH4
NRG1
PRODH
RGS4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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