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Article

Retinoic Acid Is Sufficient for the In Vitro Induction of Mouse Spermatocytes

25 Jun 2016

Abstract excerpt

Meiosis is the key step in gametogenesis. However, the mechanism of mammalian meiosis remains poorly understood due to the lack of an in vitro model. Here, we report that retinoic acid (RA) is sufficient for inducing leptotene/zygotene spermatocytes from cultured mouse spermatogonial stem cells. Multiple genes regulated by RA were identified by RNA sequencing. RA in combination with pup Sertoli cell co-culture...

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PMID: 27346680
DOI: 10.1016/j.stemcr.2016.05.013

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