Article
Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis
6 Nov 2017
Abstract excerpt
Significance Male mouse sex cells mature into sperm through a 35-d process punctuated by four transitions, two occurring before meiosis (spermatogonial differentiation and meiotic initiation) and two after meiosis (spermatid elongation and sperm release). The four transitions occur in proximity spatially and temporally, with an 8.6-d periodicity. We describe how this coordination is achieved. The premeiotic...