Article

Resistance to high-fat diet-induced weight gain in transgenic mice overexpressing human wild-type α-synuclein: A model for metabolic dysfunction in Parkinson’s disease

2024-08-30

Abstract excerpt

<title>Abstract</title> <p>Unintentional weight loss, primarily due to the loss of fat mass rather than muscle mass, is common among patients with Parkinson’s disease (PD) and is associated with poor quality of life and accelerated disease progression. Since transgenic mice overexpressing human wild-type α-synuclein (α-Syn mice) are modestly leaner than control mice, and since diabetes, a metabolic disorder, is a...

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Literature Corpus work: e1269d58-c814-5d1e-93f2-ad350a8d12f3
DOI: 10.21203/rs.3.rs-4870881/v1

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