Article
Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.
Molecular and cellular biology - 1 Oct 2005
Abell Amy N, Rivera-Perez Jaime A, Cuevas Bruce D, Uhlik Mark T, Sather Susan, Johnson Nancy L, Minton Suzanne K, Lauder Jean M, Winter-Vann Ann M, Nakamura Kazuhiro, Magnuson Terry, Vaillancourt Richard R, Heasley Lynn E, Johnson Gary L
Abstract excerpt
Skeletal disorders and neural tube closure defects represent clinically significant human malformations. The signaling networks regulating normal skeletal patterning and neurulation are largely unknown. Targeted mutation of the active site lysine of MEK kinase 4 (MEKK4) produces a kinase-inactive MEKK4 protein (MEKK4(K1361R)). Embryos homozygous for this mutation die at birth as a result of skeletal malformations...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.