Article

Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin-α7 mediated nuclear import pathway

2018-10-19

Abstract excerpt

<h4>ABSTRACT</h4> Influenza A viruses are able to adapt to restrictive conditions due to their high mutation rates. Here, we addressed the question by which mechanisms influenza A viruses may escape restriction by the cellular importin-α7 protein, a component of the nuclear import machinery required for avian-mammalian adaptation and replicative fitness in human cells. Therefore, we assessed viral evolution in mi...

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Literature Corpus work: e1105fa9-692e-507e-855a-fd918162ee53
DOI: 10.1101/447979

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