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Article

Human-like PB2 627K influenza virus polymerase activity is regulated by importin-α1 and -α7.

PLoS pathogens - 1 Jan 2012

Hudjetz Ben, Gabriel Gülsah

Abstract excerpt

Influenza A viruses may cross species barriers and transmit to humans with the potential to cause pandemics. Interplay of human- (PB2 627K) and avian-like (PB2 627E) influenza polymerase complexes with unknown host factors have been postulated to play a key role in interspecies transmission. Here, we have identified human importin-α isoforms (α1 and α7) as positive regulators of human- but not avian-like...

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Identifiers

PMID: 22275867
DOI: 10.1371/journal.ppat.1002488
PMCID: PMC3262014

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