Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier.

Abstract excerpt

Avian influenza A viruses, such as the highly pathogenic avian H5N1 viruses, sporadically enter the human population but often do not transmit between individuals. In rare cases, however, they establish a new lineage in humans. In addition to well-characterized barriers to cell entry, one major hurdle which avian viruses must overcome is their poor polymerase activity in human cells. There is compelling evidence...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adaptation, Biological
• Share to Birds
• Share to DNA-Directed RNA Polymerases