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Article

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

18 Jan 2011

Abstract excerpt

Influenza A viruses are a threat to humans due to their ability to cross species barriers, as illustrated by the 2009 H1N1v pandemic and sporadic H5N1 transmissions. Interspecies transmission requires adaptation of the viral polymerase to importin-α, a cellular protein that mediates transport into the nucleus where transcription and replication of the viral genome takes place. In this study, we analysed...

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PMID: 21245837
DOI: 10.1038/ncomms1158

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