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Article

A non-canonical glucose metabolic rewiring enables resistance to cancer targeted therapy

2024-12-20

Abstract excerpt

Targeting glucose metabolism for cancer therapy is a long-lasting pursuit but with disappointing translational success. Revelation of actionable distinctions between the malignancy traits to achieve selectivity is a prerequisite for fulfilling a therapeutic window. We discover a non-canonical glucose transporter GLUT6-facilitated, lactate-independent, glucose metabolic rewiring that selectively enables resistance...

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Identifiers and source

Literature Corpus work
e0ff8d6d-6abb-53b5-8b36-233147d4f1ae
DOI
10.1101/2024.12.19.629335
Open publication

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A non-canonical glucose metabolic rewiring enables resistance to cancer targeted therapyDOI 10.1101/2024.12.19.629335
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