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Article

Characterization of the metabolic alteration-modulated tumor microenvironment mediated by TP53 mutation and hypoxia.

Computers in biology and medicine - 1 Sept 2023

Luo Kunpeng, Qian Zhipeng, Jiang Yanan, Lv Dongxu, Zhu Kaibin, Shao Jing, Hu Ying, Lv Chengqian, Huang Qianqian, Gao Yang, Jin Shizhu, Shang Desi

Abstract excerpt

BACKGROUND: TP53 mutation and hypoxia play an essential role in cancer progression. However, the metabolic reprogramming and tumor microenvironment (TME) heterogeneity mediated by them are still not fully understood. METHODS: The multi-omics data of 32 cancer types and immunotherapy cohorts were acquired to comprehensively characterize the metabolic reprogramming pattern and the TME across cancer types and...

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Identifiers

PMID: 37356294
DOI: 10.1016/j.compbiomed.2023.107078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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