Article

Stachydrine Alleviates Thoracic Aortic Aneurysm via Targeting Lactate Dehydrogenase A in Marfan Syndrome Mice

2026-02-06

Abstract excerpt

<h4>Background: </h4> and purpose: Marfan syndrome (MFS) is a genetic disorder predominantly caused by mutations in the FBN1 gene, leading to thoracic aortic aneurysm (TAA) and lack of effective pharmacological treatments. However, the role of metabolic alterations in this process remains poorly understood. We aim to investigate the regulatory roles of metabolites in MFS. Experimental approach: Fbn1 C1041G/+ mic...

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Literature Corpus work: e0fe253d-f50d-5d8f-8ace-b3c1568a798e
DOI: 10.22541/au.177040501.19225633/v1

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