Article

Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

2022-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Marfan syndrome (MFS) is an inherited connective tissue disorder caused by mutations in the FBN1 gene encoding fibrillin-1, a matrix component of extracellular microfibrils. The main cause of morbidity and mortality in MFS is thoracic aortic aneurysm and dissection, but the underlying mechanisms remain undetermined. We found a significant increase in reactive oxygen species (ROS) generation in...

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Literature Corpus work: 3f09ce30-1ddd-5ea0-b242-45c30870e054
DOI: 10.1101/2022.01.30.478356

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