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Article

Mitochondrial Dysfunction: A New Hallmark in Hereditable Thoracic Aortic Aneurysm Development.

Cells - 21 Apr 2025

Marcos-Ríos Daniel, Rochano-Ortiz Antonio, San Sebastián-Jaraba Irene, Fernández-Gómez María José, Méndez-Barbero Nerea, Oller Jorge

Abstract excerpt

Thoracic aortic aneurysms (TAAs) pose a significant health burden due to their asymptomatic progression, often culminating in life-threatening aortic rupture, and due to the lack of effective pharmacological treatments. Risk factors include elevated hemodynamic stress on the ascending aorta, frequently associated with hypertension and hereditary genetic mutations. Among the hereditary causes, Marfan syndrome is...

Read the complete abstract on PubMed

Topics

Humans
Aortic Aneurysm, Thoracic
Mitochondria
Animals
Marfan Syndrome
Loeys-Dietz Syndrome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40277943
DOI: 10.3390/cells14080618
PMCID: PMC12026022

Genes

ACTA2
FBN1

Provenance

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