Article

Inhibition of myeloperoxidase attenuates thoracic aortic aneurysm formation in Marfan disease

2022-11-25

Abstract excerpt

Marfan syndrome (MFS) is the most prevalent inherited connective tissue disorder, still remains uncurable, and is characterized by high mortality at early age driven by dissection and rupture of thoracic aortic aneurysms. MFS is caused by mutations in the fibrillin-1 gene and aberrant TGFß signaling. Here we addressed whether myeloperoxidase (MPO), a leukocyte derived enzyme with potent matrix modulating propertie...

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Literature Corpus work: 456245ca-a6b1-54b6-a424-db6d67456be2
DOI: 10.1101/2022.11.24.517172

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