Article

An IL-2 mutein increases IL-10 and CTLA-4-dependent suppression of dendritic cells by regulatory T cells

2023-12-04

Abstract excerpt

<h4>Summary</h4> Interleukin-2 (IL-2) variants with increased CD25 dependence that selectively expand Foxp3 + regulatory T (T R ) cells are in clinical trials for treating inflammatory diseases. Using an Fc-fused IL-2 mutein (Fc.IL-2 mutein) we developed that prevents diabetes in non-obese diabetic (NOD) mice, we show that Fc.IL-2 mutein induced an activated T R population with elevated proliferation, a transc...

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Literature Corpus work: 55dd5dcb-4a63-5d73-8513-13235e98ca21
DOI: 10.1101/2023.12.01.569613

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