Article

Free spermidine evokes superoxide radicals that manifest toxicity

2021-09-05

Abstract excerpt

Spermidine and other polyamines alleviate oxidative stress, yet excess spermidine seems toxic to Escherichia coli unless it is neutralized by SpeG, an enzyme for the spermidine N-acetyl transferase function. Besides, a specific mechanism of SpeG function conferring pathogenic fitness to Staphylococcus aureus USA300 strain is unknown. Here, we provide evidence that although spermidine mitigates oxidative stress b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e0e3c8a0-1b02-536e-9d8e-9ce2e06c3c2a
DOI: 10.1101/2021.09.04.458997

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Free spermidine evokes superoxide radicals that manifest toxicityDOI 10.1101/2021.09.04.458997Read

Activation of the Spx redox sensor counters cysteine-driven Fe(II) depletion under disulfide stressSemantic proximity Read

A Novel Silver-Ruthenium-Based Antimicrobial Kills Gram-Negative Bacteria Through Oxidative Stress-Induced Macromolecular DamageSemantic proximity Read

Arginine catabolic mobile element encoded <i>speG</i> abrogates the unique hypersensitivity of <i>Staphylococcus aureus</i> to exogenous polyaminesSemantic proximity Read

Spermidine promotes lysozyme tolerance and acid stress resistance in Streptococcus pyogenes M3Semantic proximity Read

Superoxide accelerates DNA damage by elevating free-iron levels.Semantic proximity Read

Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S -Sulfhydration and Global Virulence Regulation in Staphylococcus aureusSemantic proximity Read

YpdA, a putative bacillithiol disulfide reductase, contributes to cellular redox homeostasis and virulence in Staphylococcus aureusSemantic proximity Read

Protein S-thiolation by Glutathionylspermidine (Gsp): the role of Escherichia coli Gsp synthetASE/amidase in redox regulation.Semantic proximity Read

Spermidine facilitates the adhesion and subsequent invasion of <i>Salmonella</i> Typhimurium into epithelial cells via the regulation of surface adhesive structures and the SPI-1Semantic proximity Read

Effect of Spermidine on Biofilm Formation in Escherichia coli K-12.Semantic proximity Read

Polyamines buffer labile iron to suppress ferroptosisSemantic proximity Read

The Ferrous Iron-Responsive BqsRS Two-Component System Activates Genes That Promote Cationic Stress ToleranceSemantic proximity Read