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Activation of the Spx redox sensor counters cysteine-driven Fe(II) depletion under disulfide stress

2025-12-03

Abstract excerpt

In many low G+C Gram-positive bacteria, the global regulator Spx helps maintain thiol homeostasis during disulfide stress, when protein thiols form aberrant disulfide bonds that can lead to misfolding and oxidative damage. Spx-dependent gene expression is triggered when an intramolecular disulfide bond forms between two cysteines in its redox switch. Surprisingly, some Spx functions persist even in the absence of...

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Literature Corpus work
d18cfb3c-a483-5d53-af8d-fa7e85d47ae4
DOI
10.64898/2025.12.03.692063
Open publication

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Activation of the Spx redox sensor counters cysteine-driven Fe(II) depletion under disulfide stressDOI 10.64898/2025.12.03.692063
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