Article

Polyamines buffer labile iron to suppress ferroptosis

2025-07-02

Abstract excerpt

<h4>Summary</h4> Polyamines are essential and evolutionarily conserved metabolites present at millimolar concentrations in mammalian cells. Cells tightly regulate polyamine homeostasis through complex feedback mechanisms, yet the precise role necessitating this regulation remains unclear. Here, we show that polyamines contribute to endogenous buffering of redox-active iron, providing a molecular link between poly...

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Literature Corpus work: c131da11-9114-5d63-93c7-c1a409bf4ee5
DOI: 10.1101/2025.06.30.662349

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