Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S -Sulfhydration and Global Virulence Regulation in Staphylococcus aureus

Abstract excerpt

Hydrogen sulfide (H 2 S) is thought to protect bacteria from oxidative stress, but a comprehensive understanding of its function in bacteria is largely unexplored. In this study, we show that the human pathogen Staphylococcus aureus ( S. aureus ) harbors significant effector molecules of H 2 S signaling, reactive sulfur species (RSS), as low molecular weight persulfides of bacillithiol, coenzyme A, and cysteine,...