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Article

Superoxide accelerates DNA damage by elevating free-iron levels.

Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 1996

Keyer K, Imlay J A

Abstract excerpt

Superoxide promotes hydroxyl-radical formation and consequent DNA damage in cells of all types. The long-standing hypothesis that it primarily does so by delivering electrons to adventitious iron on DNA was refuted by recent studies in Escherichia coli. Alternative proposals have suggested that superoxide may accelerate oxidative DNA damage by leaching iron from storage proteins or enzymic [4Fe-4S] clusters. The...

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Identifiers

PMID: 8942986
DOI: 10.1073/pnas.93.24.13635
PMCID: PMC19375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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