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Arginine catabolic mobile element encoded <i>speG</i> abrogates the unique hypersensitivity of <i>Staphylococcus aureus</i> to exogenous polyamines

8 Sept 2011

Abstract excerpt

Polyamines, including spermine (Spm) and spermidine (Spd), are aliphatic cations that are reportedly synthesized by all living organisms. They exert pleiotropic effects on cells and are required for efficient nucleic acid and protein synthesis. Here, we report that the human pathogen Staphylococcus aureus lacks identifiable polyamine biosynthetic genes, and consequently produces no Spm/Spd or their precursor...

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PMID: 21902734
DOI: 10.1111/j.1365-2958.2011.07809.x

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