Article

Targeting G <sub>i/o</sub> -coupled GPCRs to inhibit nociceptors: insights from the serotonin receptor Htr1b and triptans

2026-04-24

Abstract excerpt

<h4>Summary</h4> Pain perception is initiated upon activation of nociceptors of the dorsal root ganglia (DRG) and trigeminal ganglia. We identified G protein-coupled receptors (GPCRs) expressed in CGRP + mouse and human DRG neurons and found that agonists of several identified G i/o -coupled and orphan GPCRs attenuated neuronal excitability. Experiments focusing on the G i/o -coupled serotonin receptor Htr1b,...

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Literature Corpus work: 981694f7-3cdc-5e88-9f89-fc651911e0bc
DOI: 10.64898/2026.04.22.719367

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