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Article

Androgenic TRPM8 activity drives sexual dimorphism in a murine model of chronic migraine

2021-10-19

Abstract excerpt

<title>Abstract</title> <p>The mechanisms contributing to the high prevalence of chronic migraine in females are yet elusive. Here, we used a mouse model of nitroglycerin-induced chronic migraine that displays a sexual dimorphic phenotype and unveiled a role of TRPM8 as a testosterone receptor that provides antinociceptive resilience exclusively in males. Nitroglycerin induced similar mechanosensitivity to both s...

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Literature Corpus work
3a64a735-a8f5-59ec-ad77-749af1389661
DOI
10.21203/rs.3.rs-960579/v1
Open publication

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