Article

Case Study of Single-cell Protein Activity Based Drug Prediction for Precision Treatment of Cholangiocarcinoma

2022-03-02

Abstract excerpt

Cholangiocarcinoma is a rare, aggressive malignancy with limited treatment options, due to a paucity of actionable mutations and low response to immune checkpoint inhibitors. Furthermore, its extreme heterogeneity prevents identification of actionable dependencies from bulk-tissue profiles. To address these challenges, we introduce a highly generalizable, single-cell framework for the mechanism-based prioritizatio...

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Literature Corpus work: e0bea182-e885-5796-8e6d-19e35f9c78d5
DOI: 10.1101/2022.02.28.482410

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