Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata

17 May 2012

Abstract excerpt

The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are front-line therapeutics for Candida infections. Here, we provide the first global analysis of mutations accompanying the evolution of fungal drug resistance in a human host utilizing a series of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Antimicrobial Peptides and Activities
Share to Microbial Natural Products and Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22615574
DOI: 10.1371/journal.ppat.1002718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrataPMID 22615574Read ↗

Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis.Semantic proximity Read ↗

Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolatesSemantic proximity Read ↗

Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris.Semantic proximity Read ↗

Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrataSemantic proximity Read ↗

Fungal resistance to echinocandins and the MDR phenomenon in Candida glabrataSemantic proximity Read ↗

Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance?Semantic proximity Read ↗

Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure.Semantic proximity Read ↗

Micafungin exposure drives multidrug resistance in <i>Clavispora lusitaniae</i>Semantic proximity Read ↗

Echinocandin Resistance in Candida.Semantic proximity Read ↗

Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida SpeciesSemantic proximity Read ↗

Micafungin microevolution in Candida auris reveals resistance development without in vivo fitness compromise.Semantic proximity Read ↗

Multidimensional assessment of in-host fitness costs of echinocandin resistance in the opportunistic fungal pathogen Candida glabrata reveals the niche-specific requirement for FKS1 and FKS2 during infection and gut colonization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.