Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FKS2 and FKS3 Genes of Opportunistic Human Pathogen Candida albicans Influence Echinocandin Susceptibility

18 Jan 2018

Abstract excerpt

ABSTRACT Candida albicans , a prevailing opportunistic fungal pathogen of humans, has a diploid genome containing three homologous FKS genes that are evolutionarily conserved. One of these, the essential gene FKS1 , encodes the catalytic subunit of glucan synthase, which is the target of echinocandin drugs and also serves as a site of drug resistance. The other two glucan synthase-encoding genes, FKS2 and FKS3 ,...

Topics

Join the communities discussing this publication.

Antifungal resistance and susceptibility
Fungal Infections and Studies
Peptidase Inhibition and Analysis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29358288
DOI: 10.1128/aac.02299-17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FKS2 and FKS3 Genes of Opportunistic Human Pathogen Candida albicans Influence Echinocandin SusceptibilityPMID 29358288Read ↗

Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance.Semantic proximity Read ↗

Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance?Semantic proximity Read ↗

Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin.Semantic proximity Read ↗

Multidimensional assessment of in-host fitness costs of echinocandin resistance in the opportunistic fungal pathogen Candida glabrata reveals the niche-specific requirement for FKS1 and FKS2 during infection and gut colonization.Semantic proximity Read ↗

Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance.Semantic proximity Read ↗

Positions and numbers of FKS mutations in Candida albicans selectively influence in vitro and in vivo susceptibilities to echinocandin treatment.Semantic proximity Read ↗

Resistance to echinocandin-class antifungal drugs.Semantic proximity Read ↗

New insights into the echinocandin resistance in <i>Candida</i> spp. in the clinical settingSemantic proximity Read ↗

Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression.Semantic proximity Read ↗

Resistance to echinocandins comes at a cost: the impact of FKS1 hotspot mutations on Candida albicans fitness and virulence.Semantic proximity Read ↗

Critical Assessment of Cell Wall Integrity Factors Contributing to in vivo Echinocandin Tolerance and Resistance in Candida glabrataSemantic proximity Read ↗

Echinocandin Resistance in Candida.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.